Our laboratory group is committed to identifying key molecular and developmental determinants of diabetes. To this end, our work is currently focused on three questions.
- How does fetal exposure to high glucose incite poor metabolism? To study this, we have developed an innovative model of intrauterine diabetes exposure accomplished via unilateral infusion of macronutrients into the uterine artery.
- How does cystic fibrosis cause diabetes? We are working collaboratively with other University of Iowa investigators to better understand the pathophysiology of cystic fibrosis related diabetes. Our work suggests that cystic fibrosis induces a functional pancreatic islet defect independent of structural pancreatic damage.
- How does direct action of the transcription factor PPARγ in skeletal muscle help treat diabetes? We recently demonstrated that PPARγ directly augments the PDK1:AKT nexus of insulin signaling despite directly increasing muscle fatty acid uptake.
|Our team includes experienced scientists and students. Please browse these pages, reading about our research, our lab members, or view links to our publications. You may view our public resources for diabetes research. Please feel free to contact us.|| Our affiliations:|
● University of Iowa Children's Hospital
● Department of Pediatrics
● & Department of Biochemistry
→ in the Carver College of Medicine
→ at the University of Iowa
● Fraternal Order of Eagles Diabetes Research Center
● Obesity Research and Educational Initiative
- Diabetes-related molecular physiology and insulin action
- Single fuel exposures in the uterine artery
- Bioinformatic approaches to metabolism research
- Fatty acid metabolism
Support for our work has come from the Fraternal Order of Eagles Diabetes Research Center, the Center for Gene Therapy of Cystic Fibrosis and Other Genetic Diseases, the NIH, & the American Diabetes Association's Amaranth Diabetes Fund.
14-May-2013 Congratulations to Alex Sawatzke, who is graduating from medical school with research distinction based on his work in the lab. Dr. Sawatzke’s work detailed the kinetics of glucose transfer from maternal circulation to placenta to fetus, using advances to our previoiusly published PET scan-based approach.
1-Feb-2013 Our collaborative work detailing the impact of dietary fatty acid composition on insulin signaling is now available. Fish oil was able to restore insulin sensitivity and vascular dysfunction, even after obesity had been induced by a lard-based diet.
1-Oct-2012 Dr. Areej Younes, a pediatric endocrinology & diabetes fellow, joins the laboratory.
19-Sep-2012 Our collaborative work on cystic fibrosis related diabetes, with the Engelhardt lab and other investigators at the University of Iowa, is now available online at the Journal of Clinical Investigation.
10-June-2012 We presented a talk at the American Diabetes Association scientific sessions in Philadelphia describing our work on birth defects arising from high blood sugars during pregnancy.
9-Feb-2012 Dr. Michelle Baack’s work on the Ω-3 polyunsaturated fatty acid content of donor breastmilk, done in collaboration with our lab, is published.
1-Oct-2011 Dr. Erin Gordon, a pediatric intensive care fellow, joins the laboratory.
1-Jul-2011 Our lab is a recipient of a pilot project grant from the Fraternal Order of Eagles Diabetes Research Center.