Our laboratory group is committed to identifying key molecular and developmental determinants of diabetes. To this end, our work is currently focused on three questions.
- How does fetal exposure to high glucose incite poor metabolism? To study this, we have developed an innovative model of intrauterine diabetes exposure accomplished via unilateral infusion of macronutrients into the uterine artery.
- How does cystic fibrosis cause diabetes? We are working collaboratively with other University of Iowa investigators to better understand the pathophysiology of cystic fibrosis related diabetes. Our work suggests that cystic fibrosis induces a functional pancreatic islet defect independent of structural pancreatic damage.
- How can fatty acid metabolism be decoupled from insulin resistance? We recently demonstrated that PPARγ directly augments the PDK1:AKT nexus of insulin signaling despite directly increasing muscle fatty acid uptake.
|Our team includes experienced scientists and students. Please browse these pages, reading about our research, our lab members, or view links to our publications. You may view our public resources for diabetes research. Please feel free to contact us.|| Our affiliations:|
● University of Iowa Children's Hospital
● Department of Pediatrics
● & Department of Biochemistry
→ in the Carver College of Medicine
→ at the University of Iowa
● Fraternal Order of Eagles Diabetes Research Center
● Obesity Research and Educational Initiative
- Diabetes-related molecular physiology and insulin action
- Single fuel exposures in the uterine artery
- Bioinformatic approaches to metabolism research
- Fatty acid metabolism
Support for our work has come from the Fraternal Order of Eagles Diabetes Research Center, the Center for Gene Therapy, the NIH, & the American Diabetes Association's Amaranth Diabetes Fund.
May-2015 Dr. Gordon’s paper from our lab showing that hyperglycemia directly causes fetal cardiac overgrowth is published.
Apr-2015 Dr. Kua receives a Fellow Research Award at the national Society for Pediatric Research meeting in San Diego.
Feb-2015 The PET center helped us determine that the placenta has immense avidity for glucose, supporting unparalleled rates of glucose flux, as published here and reviewed in The Journal of Nuclear Medicine 56:21N.
Jan-2015 We assisted Dr. Aliye Uc’s lab determine whether loss of porcine CFTR leads to diabetes, as published here.
Jan-2015 Dr. Jamal Kriem, a pediatric gastroenterology fellow, joins the laboratory.
Mar-2014 We assisted Dr. Jeff Segar describe the influence of fetal angiotensin II on fetal cardiac remodeling, as published here.
Mar-2014 We collaborated with with Drs. Sui and Engelhardt to quantify metabolic insulin action and secretion as published here.
Jul-2013 Dr. Lim Kua, a neonatology fellow, joins the lab.
May-2013 Congratulations to Alex Sawatzke, who is graduating from medical school with research distinction based on his work in the lab. Dr. Sawatzke’s work detailed the kinetics of glucose transfer from maternal circulation to placenta to fetus, using advances to our previoiusly published PET scan-based approach.
Feb-2013 Our collaborative work detailing the impact of dietary fatty acid composition on insulin signaling is now available. Fish oil was able to restore insulin sensitivity and vascular dysfunction, even after obesity had been induced by a lard-based diet.
Oct-2012 Dr. Areej Younes, a pediatric endocrinology & diabetes fellow, joins the laboratory.
Sep-2012 Our collaborative work on cystic fibrosis related diabetes, with the Engelhardt lab and other investigators at the University of Iowa, is now available online at the Journal of Clinical Investigation.
June-2012 We presented a talk at the American Diabetes Association scientific sessions in Philadelphia describing our work on birth defects arising from high blood sugars during pregnancy.
Feb-2012 Dr. Michelle Baack’s work on the Ω-3 polyunsaturated fatty acid content of donor breastmilk, done in collaboration with our lab, is published.
Oct-2011 Dr. Erin Gordon, a pediatric intensive care fellow, joins the laboratory to study the effects of hyperglycemia on fetal heart development.
Jul-2011 Our lab is a recipient of a pilot project grant from the Fraternal Order of Eagles Diabetes Research Center.