Table of Contents

BIOGRAPHICAL SKETCH

NAME: Andrew W. Norris
POSITION: Assistant Professor of Pediatrics

EDUCATION / TRAINING

INSTITUTION AND LOCATION DEGREE YEAR(s) FIELD OF STUDY
Massachusetts Institute of TechnologyS.B. 1989Chemistry
Washington University School of Med,Ph.D. 1997Molecular Biophysics
Washington University School of MedM.D. 1997Medicine
University of Iowa Hospitals & ClinicsResidency 2000Pediatrics
Children’s Hospital, Boston, MAFellowship 2003Pediatric Endocrinology
Joslin Diabetes Center, Boston, MAFellowship 2003Pediatric Endocrinology

POSITIONS / HONORS

Positions & Employment

Year(s)PositionInstitution
2000-2003Clinical Fellow in PediatricsHarvard Medical School, Boston, MA
2003-2005Research AssociateJoslin Diabetes Center, Boston, MA
2003-2005Instructor in PediatricsHarvard Medical School, Boston, MA
2003-2005Staff PhysicianJoslin Diabetes Clinic, Boston, MA
2003-2005Assistant in EndocrinologyChildren’s Hospital, Boston, MA
2003-2005Active StaffBeth Israel Deaconess Med Ctr, Boston, MA
2005-Assistant Professor of PediatricsUniversity of Iowa College of Medicine, Iowa City IA

Honors & Awards

Massachusetts Institute of Technology
- 1989 Phi Lambda Upsilon (Chemistry Honor Society)
- 1989 Bernard Proctor Award for Undergraduate Research in Applied Biology
Washington University School of Medicine
- 1994 Trainee Investigator Award, Clinical Research Meeting
- 1995 Olin Fellow
University of Iowa Hospital & Clinics
- 1998-1999 Resident Teacher of the Year, Department of Pediatrics
- 1999-2000 Resident Teacher of the Year, Department of Pediatrics
- 1999-2000 American Academy of Pediatrics, Resident Research Grant Award
Children’s Hospital Boston
- 2001 Travel Grant, Endocrine Fellows Conference
- 2002 Genentech Travel Grant, Endocrine Society Annual Meeting
Joslin Diabetes Center
- 2004 Travel Grant, Endocrine Society
- 2004-2009 Mentored Clinical Scientist Development Award (K08)

SELECTED PEER-REVIEWED PUBLICATIONS

  1. Norris AW, Cheng L, Giguère V, Rosenberger M, & Li E. 1994. Measurement of subnanomolar retinoic acid binding affinities for cellular retinoic acid binding proteins by fluorometric titration. Biochim. Biophys. Acta 1209:10-18.
  2. Norris AW, Rong D, d’Avignon DA, Rosenberger M, Tasaki K, & Li E. 1995. Nuclear magnetic resonance studies demonstrate differences in the interaction of retinoic acid with two highly homologous retinoic acid binding proteins. Biochemistry 34:15564-15573.
  3. Norris AW & Li E. 1997. Generation and characterization of cellular retinoic acid-binding proteins from Escherichia coli expression systems. Methods Enzymol. 282:3-13.
  4. Tian K, 1)Norris AW, Lin CL, & Li E. 1997. Interaction of retinoic acid with purified heterocomplexes of retinoic acid receptor and retinoid X receptor ligand binding domains: evidence for an indirect signaling pathway. Biochemistry 36:5669-5676.
  5. Widstrom RL, Norris AW, & Spector AA. 2001. Binding of cytochrome P450 monooxygenase and lipoxygenase pathway products by heart fatty acid-binding protein. Biochemistry 40:1070-1076.
  6. Norris AW & Spector AA. 2002. Very long chain n-3 and n-6 polyunsaturated fatty acids bind strongly to liver fatty acid-binding protein. J Lipid Res. 43:646-653.
  7. Norris AW, 2)Chen L, Fisher SJ, Szanto I, Ristow M, Jozsi AC, Hirshman MF, Rosen ED, Goodyear LJ, Gonzalez FJ, Spiegelman BM, & Kahn CR. 2003 Muscle-Specific PPARγ Deficient Mice Develop Increased Adiposity and Hepatic Insulin Resistance but Respond to Thiazolidinediones. J Clin Invest 112:608-618
  8. Widstrom RL, Norris AW, Van Der Veer J, & Spector AA. 2003. Fatty acid-binding proteins inhibit hydration of epoxyeicosatrienoic acids by soluble epoxide hydrolase. Biochemistry 42:11762-11767.
  9. Norris AW & Svoren BM. 2005. Complications and Co-Morbidities of Type 2 Diabetes in Youth. Pediatr Ann 34:710-718.
  10. Norris AW & Kahn CR. 2006. Analysis of gene expression in pathophysiological states: balancing false discovery and false negative rates. Proc Natl Acad Sci USA 103:649-653.
  11. Gesta S, Bluher M, Yamamoto Y, Norris AW, Berndt J, Kralisch S, Boucher J, Lewis C, & Kahn CR. 2006. Evidence for a role of developmental genes in the origin of obesity and body fat distribution. Proc Natl Acad Sci USA 103:6676-81.
  12. Spector AA & Norris AW. 2007. Action of epoxyeicosatrienoic acids (EETs) on cellular function. Am J Physiol Cell Physiol. 292:C996-1012.
  13. Katic M, Kennedy AR, Leykin I, Norris A, McGettrick A, Gesta S, Russell SJ, Bluher M, Maratos-Flier E, & Kahn CR. 2007. Mitochondrial gene expression and increased oxidative metabolism: role in increased lifespan of fat-specific insulin receptor knock-out mice. Aging Cell. 6:827-839.
  14. Tseng YH, Kokkotou E, Schulz TJ, Huang TL, Winnay JN, Taniguchi CM, Tran TT, Suzuki R, Espinoza DO, Yamamoto Y, Ahrens MJ, Dudley AT, Norris AW, Kulkarni RN, & Kahn CR. 2008. New Role of Bone Morphogenetic Protein 7 in Brown Adipogenesis and Energy Expenditure. Nature. 454:1000-1004.
  15. Norris AW, Hirshman MF, Yao J, Jessen N, Musi N, Chen L, Sivitz WI, Goodyear LJ, & Kahn CR. 2008. Endogenous Peroxisome Proliferator-Activated Receptor γ Augments Fatty Acid Uptake in Oxidative Muscle. Endocrinology. 149:5374-5383.
  16. Segar EM, Norris AW, Yao JR, Hu S, Koppehnafer SL, Roghair RD, Segar JL, & Scholz TD. Programming of growth, insulin resistance and vascular dysfunction in offspring of late gestation diabetic rats. Clin Sci (Lond). 117:129–138.
1) K Tian and AW Norris contributed equally to this work
2) AW Norris and L Chen contributed equally to this work