====== BIOGRAPHICAL SKETCH ====== **NAME:** Andrew W. Norris\\ **POSITION:** Assistant Professor of Pediatrics =====EDUCATION / TRAINING ===== ^ INSTITUTION AND LOCATION ^ DEGREE ^ YEAR(s) ^ FIELD OF STUDY | |Massachusetts Institute of Technology|S.B.| 1989|Chemistry| |Washington University School of Med,|Ph.D.| 1997|Molecular Biophysics| |Washington University School of Med|M.D.| 1997|Medicine| |University of Iowa Hospitals & Clinics|Residency| 2000|Pediatrics| |Children's Hospital, Boston, MA|Fellowship| 2003|Pediatric Endocrinology| |Joslin Diabetes Center, Boston, MA|Fellowship| 2003|Pediatric Endocrinology| ===== POSITIONS / HONORS ===== ==== Positions & Employment ==== ^Year(s)^Position^Institution| |2000-2003|Clinical Fellow in Pediatrics|Harvard Medical School, Boston, MA| |2003-2005|Research Associate|Joslin Diabetes Center, Boston, MA| |2003-2005|Instructor in Pediatrics|Harvard Medical School, Boston, MA| |2003-2005|Staff Physician|Joslin Diabetes Clinic, Boston, MA| |2003-2005|Assistant in Endocrinology|Children's Hospital, Boston, MA| |2003-2005|Active Staff|Beth Israel Deaconess Med Ctr, Boston, MA| |2005-|Assistant Professor of Pediatrics|University of Iowa College of Medicine, Iowa City IA| ==== Honors & Awards ==== |**Massachusetts Institute of Technology**\\ - 1989 Phi Lambda Upsilon (Chemistry Honor Society)\\ - 1989 Bernard Proctor Award for Undergraduate Research in Applied Biology\\ **Washington University School of Medicine**\\ - 1994 Trainee Investigator Award, Clinical Research Meeting\\ - 1995 Olin Fellow\\ **University of Iowa Hospital & Clinics**\\ - 1998-1999 Resident Teacher of the Year, Department of Pediatrics\\ - 1999-2000 Resident Teacher of the Year, Department of Pediatrics\\ - 1999-2000 American Academy of Pediatrics, Resident Research Grant Award\\ **Children's Hospital Boston**\\ - 2001 Travel Grant, Endocrine Fellows Conference\\ - 2002 Genentech Travel Grant, Endocrine Society Annual Meeting\\ **Joslin Diabetes Center**\\ - 2004 Travel Grant, Endocrine Society\\ - 2004-2009 Mentored Clinical Scientist Development Award (K08) | ===== SELECTED PEER-REVIEWED PUBLICATIONS ===== -[[team#andrew_w_norris_m.d._ph.d|Norris AW]], Cheng L, Giguère V, Rosenberger M, & Li E. 1994. Measurement of subnanomolar retinoic acid binding affinities for cellular retinoic acid binding proteins by fluorometric titration. __//Biochim. Biophys. Acta//__ 1209:10-18. -[[team#andrew_w_norris_m.d._ph.d|Norris AW]], Rong D, d'Avignon DA, Rosenberger M, Tasaki K, & Li E. 1995. Nuclear magnetic resonance studies demonstrate differences in the interaction of retinoic acid with two highly homologous retinoic acid binding proteins. __//Biochemistry//__ 34:15564-15573. -[[team#andrew_w_norris_m.d._ph.d|Norris AW]] & Li E. 1997. Generation and characterization of cellular retinoic acid-binding proteins from Escherichia coli expression systems. __//Methods Enzymol.//__ 282:3-13. -Tian K, ((K Tian and AW Norris contributed equally to this work))[[team#andrew_w_norris_m.d._ph.d|Norris AW]], Lin CL, & Li E. 1997. Interaction of retinoic acid with purified heterocomplexes of retinoic acid receptor and retinoid X receptor ligand binding domains: evidence for an indirect signaling pathway. __//Biochemistry//__ 36:5669-5676. -Widstrom RL, [[team#andrew_w_norris_m.d._ph.d|Norris AW]], & Spector AA. 2001. Binding of cytochrome P450 monooxygenase and lipoxygenase pathway products by heart fatty acid-binding protein. __//Biochemistry//__ 40:1070-1076. -[[team#andrew_w_norris_m.d._ph.d|Norris AW]] & Spector AA. 2002. Very long chain n-3 and n-6 polyunsaturated fatty acids bind strongly to liver fatty acid-binding protein. __//J Lipid Res.//__ 43:646-653. -[[team#andrew_w_norris_m.d._ph.d|Norris AW]], ((AW Norris and L Chen contributed equally to this work))Chen L, Fisher SJ, Szanto I, Ristow M, Jozsi AC, Hirshman MF, Rosen ED, Goodyear LJ, Gonzalez FJ, Spiegelman BM, & Kahn CR. 2003 Muscle-Specific PPARγ Deficient Mice Develop Increased Adiposity and Hepatic Insulin Resistance but Respond to Thiazolidinediones. __//J Clin Invest//__ 112:608-618 -Widstrom RL, [[team#andrew_w_norris_m.d._ph.d|Norris AW]], Van Der Veer J, & Spector AA. 2003. Fatty acid-binding proteins inhibit hydration of epoxyeicosatrienoic acids by soluble epoxide hydrolase. __//Biochemistry//__ 42:11762-11767. -[[team#andrew_w_norris_m.d._ph.d|Norris AW]] & Svoren BM. 2005. Complications and Co-Morbidities of Type 2 Diabetes in Youth. __//Pediatr Ann//__ 34:710-718. -[[team#andrew_w_norris_m.d._ph.d|Norris AW]] & Kahn CR. 2006. Analysis of gene expression in pathophysiological states: balancing false discovery and false negative rates. __//Proc Natl Acad Sci USA//__ 103:649-653. -Gesta S, Bluher M, Yamamoto Y, [[team#andrew_w_norris_m.d._ph.d|Norris AW]], Berndt J, Kralisch S, Boucher J, Lewis C, & Kahn CR. 2006. Evidence for a role of developmental genes in the origin of obesity and body fat distribution. __//Proc Natl Acad Sci USA//__ 103:6676-81. -Spector AA & [[team#andrew_w_norris_m.d._ph.d|Norris AW]]. 2007. Action of epoxyeicosatrienoic acids (EETs) on cellular function. __//Am J Physiol Cell Physiol.//__ 292:C996-1012. - Katic M, Kennedy AR, Leykin I, [[team#andrew_w_norris_m.d._ph.d|Norris A]], McGettrick A, Gesta S, Russell SJ, Bluher M, Maratos-Flier E, & Kahn CR. 2007. Mitochondrial gene expression and increased oxidative metabolism: role in increased lifespan of fat-specific insulin receptor knock-out mice. __//Aging Cell//__. 6:827-839. - Tseng YH, Kokkotou E, Schulz TJ, Huang TL, Winnay JN, Taniguchi CM, Tran TT, Suzuki R, Espinoza DO, Yamamoto Y, Ahrens MJ, Dudley AT, [[team#andrew_w_norris_m.d._ph.d|Norris AW]], Kulkarni RN, & Kahn CR. 2008. New Role of Bone Morphogenetic Protein 7 in Brown Adipogenesis and Energy Expenditure. __//Nature//__. 454:1000-1004. - [[team#andrew_w_norris_m.d._ph.d|Norris AW]], Hirshman MF, [[team#jianrong_yao_ph.d|Yao J]], Jessen N, Musi N, Chen L, Sivitz WI, Goodyear LJ, & Kahn CR. 2008. Endogenous Peroxisome Proliferator-Activated Receptor γ Augments Fatty Acid Uptake in Oxidative Muscle. __//Endocrinology//__. 149:5374-5383. - Segar EM, [[team#andrew_w_norris_m.d._ph.d|Norris AW]], [[team#jianrong_yao_ph.d|Yao JR]], [[team#shanming_hu|Hu S]], Koppehnafer SL, Roghair RD, Segar JL, & Scholz TD. Programming of growth, insulin resistance and vascular dysfunction in offspring of late gestation diabetic rats. __//Clin Sci (Lond)//__. 117:129–138.